Complex geological factors such as fractures， faults， weak surface structures in unconformity contact， and multiple pressure systems in Sichuan-Chongqing region result in multi-layers and multi-mechanisms leakage in the same open hole. The traditional plugging technology has problems such as slow establishment of pumping channels for large particle plugging materials， long plugging time， and poor stability of existing plugging tools， resulting in slow effectiveness and low efficiency， which poses challenges to the normal development of drilling work. In view of this， this article adopted the working principle of quickly establishing a plugging channel by switching flow channels through ground injection of work balls，carried out optimization design of repeatable on-off fast circulating valve， formulated leak sealing operation processes， and completed the research on multiple leakage layers plugging without tripping out based on fast circulating valve. Through on-site drilling applications， it is possible to achieve plugging up to 5 leakage layers without tripping out and on-site test improved the efficiency of plugging operations by 74% and reduced the cost of plugging. This provides a new technological means for quickly plugging complex leakage layers while drilling.