The problem of lost circulation occurs frequently during geothermal well exploration and development, especially the total loss of geothermal reservoir. Lost circulation brings about wellbore stability and drilling efficiency. Geothermal DR2024 well is located in Xining city, Qinghai Province, which is a geothermal mining well. When drilling to the non-target geothermal reservoir well section of 714m to 759m, the total loss occurred.