The exploration intensity of oil and gas resources in the Qiangtang Basin is not high， and a large number of blank areas need further exploration. Geological survey wells are an important engineering tool for the investigation and research of oil and gas resources in the Qiangtang Basin. Wireline core drilling technology is commonly used to obtain the high quality in-situ cores and logging channels for the entire borehole， which has gradually replaced the conventional core drilling technology over the past decade. The Qiangtang Basin has a unique geographical location and climatic conditions， with complex geological conditions. The application of wireline coring drilling technology in this area has encountered many construction difficulties. This paper combines the lithological testing data and geological stress conditions to analyze and clarify that the wireline coring drilling process and the non-coring oil and gas drilling process are significantly different in terms of well configuration， drilling parameters， drilling fluid， plugging and surging， thus relevant parameter indicators and practical experience cannot be simply copied. At the same time， typical problems of geological survey wells in the Qiangtang Basin over the years were sorted out and analyzed in detail， aspects such as wellbore stability， drilling fluid， drilling leakage， and engineering implementation are elaborated， which can provide important references for the design and operation of geological survey wells in the region.